Ammonium Hydroxide → Ammonium Chloride

Participants

Reaction Steps

A solution of 2-(2-aminoethylthiomethyl)-3-mercaptopyridine dihydrochloride (0.40 g) in water (4 mL) basified with addition of concentrated ammonium hydroxide and a stream of air was bubbled through it for 16 hours. Reaction mixture was evaporated to dryness to produce solid residue of title product and ammonium chloride which was used for next step without further purification. 1H NMR (D2O) δ 2.75 (t, J=6H, 2H), 3.15 (t, J=6H, 2H), 4.00 (s, 2H), 7.38 (dd, J=4, J=6, 1H), 8.21 (d, J=6, 1H), 8.38 (d, J=4, 1H).

Provenance & Evidence