Ammonium Hydroxide → Ammonium Chloride

HRID 2085979Notes

Reaction equation

HRID 2085979 reaction equation
[ClH:1].Cl.[NH2:3][CH2:4][CH2:5][S:6][CH2:7][C:8]1[C:13]([SH:14])=[CH:12][CH:11]=[CH:10][N:9]=1.[OH-].[NH4+:16]>O>[NH2:3][CH2:4][CH2:5][S:6][CH2:7][C:8]1[C:13]([S:14][S:14][C:13]2[C:8]([CH2:7][S:6][CH2:5][CH2:4][NH2:3])=[N:16][CH:10]=[CH:11][CH:12]=2)=[CH:12][CH:11]=[CH:10][N:9]=1.[Cl-:1].[NH4+:3]

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 9795503HCID 9795503, compound

Product 2

HCID 25517Ammonium ChlorideHCID 9843827HCID 9843827, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2-(2-aminoethylthiomethyl)-3-mercaptopyridine dihydrochloride (0.40 g) in water (4 mL) basified with addition of concentrated ammonium hydroxide and a stream of air was bubbled through it for 16 hours. Reaction mixture was evaporated to dryness to produce solid residue of title product and ammonium chloride which was used for next step without further purification. 1H NMR (D2O) δ 2.75 (t, J=6H, 2H), 3.15 (t, J=6H, 2H), 4.00 (s, 2H), 7.38 (dd, J=4, J=6, 1H), 8.21 (d, J=6, 1H), 8.38 (d, J=4, 1H).

Workup

  1. customa stream of air was bubbled through it for 16 hours
  2. customReaction mixture
  3. customwas evaporated to dryness

Sources & evidence

ORD record
ord-fb2ded1d79674b74ba3c7c744bf411ab
Source dataset
uspto-grants-2004_04
Patent number
US06723716B1

Reaction notes

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