反应详情

Prepared from the compound of Example 2 and morpholine. To a solution of 2-chloro-N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-acetamide (45 mg) in N,N-dimethylformamide (10 mL) was added potassium phosphate (68 mg) and morpholine (0.017 mL). The solution stirred at room temperature for 5 hours followed by evaporation of the solvent. The light brown product was washed with water and filtered (30 mg). 1H-NMR (300 MHz, DMSO-d6), 11.68 (br s, 1H), 9.85 (br s, 1H), 8.64 (s, 1H), 8.33 (d, J=9.0 Hz, 2H), 7.89 (t, 1H), 7.77 (d, J=9.0 Hz, 1H), 7.66 (t, 1H), 7.32 (d, J=9.0 Hz, 1H), 3.68 (d, 4), 3.17 (s, 2H), 2.55 (m, 4H).

1. customfollowed by evaporation of the solvent
2. washThe light brown product was washed with water
3. filtrationfiltered (30 mg)