Ethanol → 1-[3-(6-Bromo-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]pyrrolidin-2-one

HRID 2086071Notes

Reaction equation

HRID 2086071 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([N+:21]([O-])=O)[C:5]([NH:8][C:9]2[CH:10]=[C:11]([N:15]3[CH2:19][CH2:18][CH2:17][C:16]3=[O:20])[CH:12]=[CH:13][CH:14]=2)=[N:6][CH:7]=1.[CH2:24](O)C>>[Br:1][C:2]1[CH:3]=[C:4]2[N:21]=[CH:24][N:8]([C:9]3[CH:10]=[C:11]([N:15]4[CH2:19][CH2:18][CH2:17][C:16]4=[O:20])[CH:12]=[CH:13][CH:14]=3)[C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 22727951HCID 22727951, compound

Product 1

HCID 227279581-[3-(6-Bromo-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]pyrrolidin-2-one

Procedure

1-[3-(6-Bromo-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]pyrrolidin-2-one was prepared from 1-[3-(5-bromo-3-nitropyridin-2-ylamino)phenyl]pyrrolidin-2-one as described in Example 1. Oxalate salt, white crystals, m.p. 194-195° C. (from ethanol); δH (360 MHz, d6-DMSO) 2.10 (2H, quin, J 7), 2.56 (2H, t, J 8), 3.92 (2H, t, J 7), 7.58-7.65 (2H, m), 7.78-7.81 (1H, m), 8.19 (1H, s), 8.52-8.54 (2H, m), 8.93 (1H, s); m/z (ES+) 357 and 359 (M++H).

Sources & evidence

ORD record
ord-73de8af29c9b47f193e6d6566901187b
Source dataset
uspto-grants-2004_04
Patent number
US06723735B1

Reaction notes

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