Phenylboronic Acid → HCID 9841241, compound

HRID 2086082Notes

Reaction equation

HRID 2086082 reaction equation
Br[C:2]1[CH:3]=[C:4]2[N:10]=[CH:9][N:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:12]=3)[C:5]2=[N:6][CH:7]=1.[C:23]1(B(O)O)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(O)C>[C:23]1([C:2]2[CH:3]=[C:4]3[N:10]=[CH:9][N:8]([C:11]4[CH:16]=[CH:15][CH:14]=[C:13]([C:17]5[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=5)[CH:12]=4)[C:5]3=[N:6][CH:7]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 66827Phenylboronic AcidHCID 11152319HCID 11152319, compound

Product 1

HCID 9841241HCID 9841241, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from 6-bromo-3-[3-(pyridin-3-yl)phenyl]-3H-imidazo[4,5-b]pyridine and phenylboronic acid as described in Example 1. Free base, white powder, m.p. 179-180° C. (from ethanol); δH (400 MHz, CDCl3) 7.41-7.44 (1H, m), 7.52 (2H, t, J 7), 7.65-7.74 (4H, m), 7.83 (1H, d, J 8), 7.97 (1H, d, J 8), 8.07 (1H, s), 8.35 (1H, d, J 2), 8.44 (1H, s), 8.49 (1H, s), 8.65 (1H, d, J 5), 8.72 (1H, s), 8.95 (1H, s); m/z (ES+) 349 (M++H).

Sources & evidence

ORD record
ord-7e72e9ba8efc47ceac35a770604c659a
Source dataset
uspto-grants-2004_04
Patent number
US06723735B1

Reaction notes

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