Triethylamine → HCID 135817480, compound

HRID 2086103Notes

Reaction equation

HRID 2086103 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9]([C:11]3[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=3[OH:18])=[N:8][C:7](=O)[C:6]=2[CH:20]=1.Cl.[NH:22]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)[NH2:23].C(N(CC)CC)C>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:10])=[C:6]([C:7]2[N:8]=[C:9]([C:11]3[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=3[OH:18])[N:22]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=3)[N:23]=2)[CH:20]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 22728054HCID 22728054, compoundHCID 135817451HCID 135817451, compound

Product 1

HCID 135817480HCID 135817480, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.0 g of 6-chloro-2-(5-chloro-2-hydroxyphenyl)benz[e][1,3]oxazin-4-one are boiled under reflux for 5 h with 1.7 g of 2-hydrazinomethylpyridine hydrochloride and 3 ml of triethylamine in 50 ml of ethanol. The crystals precipitating on cooling are washed with ethanol. After drying, 3,5-bis(5-chloro-2-hydroxyphenyl)-1-(pyridin-2-ylmethyl)-1H-[1,2,4]triazole remains as colorless crystals of m.p. 227-229 C.

Workup

  1. customThe crystals precipitating
  2. temperatureon cooling
  3. washare washed with ethanol
  4. customAfter drying

Sources & evidence

ORD record
ord-d81b30ca75a84f2e9b69bec4f9f6fdae
Source dataset
uspto-grants-2004_04
Patent number
US06723742B2

Reaction notes

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