Hydrazine hydrate (1:1) → 1-(4-Pyridyl)-4-piperidone Hydrazone

HRID 2086269Notes

Reaction equation

HRID 2086269 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.O.[NH2:15][NH2:16]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][C:10](=[N:15][NH2:16])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 113327931-(Pyridin-4-yl)piperidin-4-one

Product 1

HCID 227272021-(4-Pyridyl)-4-piperidone Hydrazone

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-(4-pyridyl)-4-piperidone (3.52 g) and hydrazine hydrate (1.25 q) in ethanol (50 ml) was stirred at room temperature for 15 hours. The reaction mixture was concentrated and the residue obtained was crystallized from ether to obtain [1-(4-pyridyl)-4-piperidinylidene]hydrazine (3.51 g) as colorless crystals.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue obtained
  3. customwas crystallized from ether

Sources & evidence

ORD record
ord-d749fecd6fce440cb94d40540530ff39
Source dataset
uspto-grants-2004_04
Patent number
US06723722B1

Reaction notes

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