Trifluoroacetic acid → 4-(6-Chloronaphthalene-2-sulfonyl)-1-{[1-(4-pyridyl)-4-piperidinyl](2,2,2-trifluoroethyl)amino}-2-piperazinone

HRID 2086293Notes

Reaction equation

HRID 2086293 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([NH:21][CH:22]3[CH2:27][CH2:26][N:25]([C:28]4[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=4)[CH2:24][CH2:23]3)[C:17](=[O:34])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.[F:35][C:36]([F:41])([F:40])[C:37](O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([N:21]([CH:22]3[CH2:27][CH2:26][N:25]([C:28]4[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=4)[CH2:24][CH2:23]3)[CH2:37][C:36]([F:41])([F:40])[F:35])[C:17](=[O:34])[CH2:16]1)(=[O:13])=[O:14])[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178254104-(6-Chloronaphthalene-2-sulfonyl)-1-[1-(4-pyridyl)-4-piperidinylamino]-2-piperazinone

Product 1

HCID 227272534-(6-Chloronaphthalene-2-sulfonyl)-1-{[1-(4-pyridyl)-4-piperidinyl](2,2,2-trifluoroethyl)amino}-2-piperazinone

Procedure

Similarly to Method B in Example 43 and using 4-(6-chloronaphthalene-2-sulfonyl)-1-[1-(4-pyridyl)-4-piperidinylamino}-2-piperazinone (200 mg) and trifluoroacetic acid (5 ml) instead of acetic acid, the title compound (37 mg) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-235af3336d6747d487c7c7649981bbfe
Source dataset
uspto-grants-2004_04
Patent number
US06723722B1

Reaction notes

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