HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-ol → 4-[(6-Chloro-2-naphthyl)sulfonyl]-6-[(4-hydroxy-1-piperidinyl)carbonyl]-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-2-piperazinone Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | 4-[(6-Chloro-2-naphthyl)sulfonyl)-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazinecarboxylic Acid | HCID 22727237 | — |
| Product | 4-[(6-Chloro-2-naphthyl)sulfonyl]-6-[(4-hydroxy-1-piperidinyl)carbonyl]-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-2-piperazinone Hydrochloride | HCID 22727036 | 107.1% |
Reaction Steps
Similarly to Example 116 and using 4-[(6-chloro-2-naphthyl)sulfonyl)-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazinecarboxylic acid (0.20 g) obtained in Example 110 and 4-hydroxypiperidine (0.051 g), the title compound (0.13 g) was obtained as a yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723722B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-91425b1fd22c482dbd74fadae20fee38 |
| Source note | uspto-grants-2004_04 |