Piperidin-4-ol → 4-[(6-Chloro-2-naphthyl)sulfonyl]-6-[(4-hydroxy-1-piperidinyl)carbonyl]-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-2-piperazinone Hydrochloride

HRID 2086309Notes

Reaction equation

HRID 2086309 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][C:19](=[O:21])[N:18]([N:22]([CH3:35])[CH:23]3[CH2:28][CH2:27][N:26]([C:29]4[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=4)[CH2:25][CH2:24]3)[CH:17]([C:36](O)=[O:37])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.[OH:39][CH:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:16][CH:17]([C:36]([N:43]3[CH2:44][CH2:45][CH:40]([OH:39])[CH2:41][CH2:42]3)=[O:37])[N:18]([N:22]([CH3:35])[CH:23]3[CH2:24][CH2:25][N:26]([C:29]4[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=4)[CH2:27][CH2:28]3)[C:19](=[O:21])[CH2:20]1)(=[O:13])=[O:14])[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 227272374-[(6-Chloro-2-naphthyl)sulfonyl)-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazinecarboxylic Acid

Product 1

HCID 227270364-[(6-Chloro-2-naphthyl)sulfonyl]-6-[(4-hydroxy-1-piperidinyl)carbonyl]-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-2-piperazinone HydrochlorideYield 107.1%

Procedure

Similarly to Example 116 and using 4-[(6-chloro-2-naphthyl)sulfonyl)-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazinecarboxylic acid (0.20 g) obtained in Example 110 and 4-hydroxypiperidine (0.051 g), the title compound (0.13 g) was obtained as a yellow powder.

Sources & evidence

ORD record
ord-91425b1fd22c482dbd74fadae20fee38
Source dataset
uspto-grants-2004_04
Patent number
US06723722B1

Reaction notes

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