HCID 22725080, compound → HCID 22725104, compound

HRID 2086591Notes

Reaction equation

HRID 2086591 reaction equation
[N:1]([CH2:4][C:5]1[C:6]([C:11]2([OH:34])[CH2:17][CH:16]3[N:18]([CH:19]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[Cl:33])[C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[Cl:26])[CH:13]([CH2:14][CH2:15]3)[CH2:12]2)=[N:7][CH:8]=[CH:9][CH:10]=1)=[N+]=[N-]>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[NH2:1][CH2:4][C:5]1[C:6]([C:11]2([OH:34])[CH2:12][CH:13]3[N:18]([CH:19]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[Cl:26])[C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[Cl:33])[CH:16]([CH2:15][CH2:14]3)[CH2:17]2)=[N:7][CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 1

HCID 22725080HCID 22725080, compound

Product 1

HCID 22725104HCID 22725104, compound

Reagents, catalysts & solvents 1

HCID 131709914Lindlars catalystCatalyst

Procedure

Follow the procedure of Step 6 of Example 15, using the product from Step 5 (69 mg) and Lindlar catalyst (7 mg) to produce the title compound. 1H NMR (CDCl3) 8.40 (d, 1H), 7.95 (d, 2H), 775 (d, 1H), 7.05-7.15 (m, 7H), 5.60 (s, 1H), 5.25 (b, s, 1H), 4.40 (s, 2H), 3.20 (s, br, 2H), 2.50 (dd, 2H), 2.3 (m, 4H), 1.75 (d, 2H).

Sources & evidence

ORD record
ord-898664b7a0514134978f5e42f3a4af1f
Source dataset
uspto-grants-2004_04
Patent number
US06727254B2

Reaction notes

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