Imidazole → HCID 53924662, compound

HRID 2086724Notes

Reaction equation

HRID 2086724 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][C:8]=1[OH:9])[CH3:2].[Si:13](Cl)([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14].N1C=CN=C1.O>CN(C=O)C>[Si:13]([O:9][C:8]1[CH:7]=[CH:6][C:5]([C:10](=[O:12])[CH3:11])=[CH:4][C:3]=1[CH2:1][CH3:2])([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]

Participants

6

Reactant 4

HCID 795ImidazoleHCID 962WaterHCID 28928tert-Butyldimethylsilyl chlorideHCID 137241431-(3-Ethyl-4-hydroxyphenyl)ethan-1-one

Product 1

HCID 53924662HCID 53924662, compoundYield 78.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a stirred solution of 1-(3-ethyl-4-hydroxyphenyl)-1-ethanone (9.24 g, 56.27 mmol) in DMF (60 ml) was added tert-butyldimethylsilyl chloride (9.33 g, 61.9 mmol), imidazole (4.6 g, 67.52 mmol), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into water. The whole was extracted with ethyl acetate. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The residue was fractionally distilled under reduced pressure 180° c., 0.5 mmHg) to give title compound (12.3 g, 78% yield).

Workup

  1. extractionThe whole was extracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo
  5. distillationThe residue was fractionally distilled under reduced pressure 180° c

Sources & evidence

ORD record
ord-be95c9f9c4844444915e9c79e6e6ae82
Source dataset
uspto-grants-2004_04
Patent number
US06727238B2

Reaction notes

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