HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-(3-Iodophenylamino)-3-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Iodoaniline | HCID 12271 | — |
| Reactant | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(3-Iodophenylamino)-3-nitropyridine | HCID 22724483 | 21.2% |
Reaction Steps
A mixture of 2-chloro-3-nitropyridine (8.5 g), 3-iodoaniline (12.5 g) and potassium carbonate (9.0 g) in 1,4-dioxane (100 ml) was stirred under reflux for 20 hours. After cooling, insoluble materials were removed by filtration and the filtrate was concentrated. The resultant solid was collected and washed with isopropyl ether to give 2-(3-iodophenylamino)-3-nitropyridine (3.88 g) as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727245B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-aa96f6c247b04d4d8ff5e66af37f27b9 |
| Source note | uspto-grants-2004_04 |