反应详情

A mixture of 2-chloro-3-nitropyridine (8.5 g), 3-iodoaniline (12.5 g) and potassium carbonate (9.0 g) in 1,4-dioxane (100 ml) was stirred under reflux for 20 hours. After cooling, insoluble materials were removed by filtration and the filtrate was concentrated. The resultant solid was collected and washed with isopropyl ether to give 2-(3-iodophenylamino)-3-nitropyridine (3.88 g) as an orange solid.

1. temperatureunder reflux for 20 hours
2. temperatureAfter cooling
3. custominsoluble materials were removed by filtration
4. concentrationthe filtrate was concentrated
5. customThe resultant solid was collected
6. washwashed with isopropyl ether