反应详情

A mixture of 2-chloro-3-nitropyridine (3.20 g), methyl 3,5-diaminobenzoate (3.20 g) and potassium carbonate (4.0 g) in 1,4-dioxane (60 ml) was stirred under reflux for 4 hours. After cooling, insoluble materials were removed by filtration and the filtrate was concentrated. The residue was chromatographed on silica gel column (5% methanol in chloroform) to give 2-(3-amino-5-methoxycarbonylphenylamino)-3-nitropyridine (1.12 g).

1. temperatureunder reflux for 4 hours
2. temperatureAfter cooling
3. custominsoluble materials were removed by filtration
4. concentrationthe filtrate was concentrated
5. customThe residue was chromatographed on silica gel column (5% methanol in chloroform)