HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → HCID 22724459, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 22724273 | HCID 22724273 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 22724459 | HCID 22724459 | 66.1% |
Reaction Steps
A suspension of 4-[3-(4-acetylaminophenyl)phenyl]-2-benzyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (963 mg) in 3N hydrochloric acid (25 ml) was stirred under reflux for 3 hours. Then the mixture was poured into ice-water and alkalinized with sodium bicarbonate. The resultant solid was collected and washed with water to give 4-[3-(4-aminophenyl)phenyl]-2-benzyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (577 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06727245B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-97b7cefef7bb4ec689d9bc24d78b5cb8 |
| Source note | uspto-grants-2004_04 |