Sodium Bicarbonate → HCID 22724459, compound

HRID 2086864Notes

Reaction equation

HRID 2086864 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]([N:17]3[C:22](=[O:23])[C:21]([CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[N:20][C:19]4[CH:31]=[CH:32][CH:33]=[N:34][C:18]3=4)[CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)(=O)C.C(=O)(O)[O-].[Na+]>Cl>[NH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]([N:17]3[C:22](=[O:23])[C:21]([CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[N:20][C:19]4[CH:31]=[CH:32][CH:33]=[N:34][C:18]3=4)[CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 22724273HCID 22724273, compound

Product 1

HCID 22724459HCID 22724459, compoundYield 66.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of 4-[3-(4-acetylaminophenyl)phenyl]-2-benzyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (963 mg) in 3N hydrochloric acid (25 ml) was stirred under reflux for 3 hours. Then the mixture was poured into ice-water and alkalinized with sodium bicarbonate. The resultant solid was collected and washed with water to give 4-[3-(4-aminophenyl)phenyl]-2-benzyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (577 mg).

Workup

  1. temperatureunder reflux for 3 hours
  2. customThe resultant solid was collected
  3. washwashed with water

Sources & evidence

ORD record
ord-97b7cefef7bb4ec689d9bc24d78b5cb8
Source dataset
uspto-grants-2004_04
Patent number
US06727245B2

Reaction notes

Loading…