HCID 22218541, compound → HCID 22723933, compound

HRID 2087067Notes

Reaction equation

HRID 2087067 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C[Si](O[Cr](O[Si](C)(C)C)(=O)=O)(C)C>ClCCl>[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]=[O:19])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 22218541HCID 22218541, compoundHCID 178504317HCID 178504317, compound

Product 1

HCID 22723933HCID 22723933, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 542.9 mg (2.0 mmol) of 12-(4-morpholinyl)-1-dodecanol and 3.0 g of (5.10 mmol) of bis(trimethylsilyl)chromate (M. Heravi, Monatsh. Chem. 1998, 129(12), 1305-1308) in 10 ml of dichloromethane is stirred at room temperature overnight and filtered. After removal of the dichloromethane, the residue is purified by silica gel column chromatography to give 210 mg (39%) of 12-(4-morpholinyl)-1-dodecanal.

Workup

  1. filtrationfiltered
  2. customAfter removal of the dichloromethane
  3. customthe residue is purified by silica gel column chromatography

Sources & evidence

ORD record
ord-99b844f5652c41ae9aff0438d2fcd9c9
Source dataset
uspto-grants-2004_04
Patent number
US06727232B2

Reaction notes

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