Acetic Acid → 3-n-Butyl-6-[4-(2-hydroxyethyl)aminophenyl]uracil

HRID 2087121Notes

Reaction equation

HRID 2087121 reaction equation
Cl[C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH2:11][CH3:12])[C:4](=[O:13])[CH:3]=1.[NH2:14][C:15]1[CH:20]=[CH:19][C:18](CCO)=[CH:17][CH:16]=1.C(N(C(C)C)C(C)C)C.[C:33](O)(=[O:35])[CH3:34]>O>[CH2:9]([N:5]1[C:4](=[O:13])[CH:3]=[C:2]([C:18]2[CH:17]=[CH:16][C:15]([NH:14][CH2:34][CH2:33][OH:35])=[CH:20][CH:19]=2)[NH:7][C:6]1=[O:8])[CH2:10][CH2:11][CH3:12]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 669044-Aminophenethyl alcoholHCID 81531DiisopropylethylamineHCID 141001713-butyl-6-chloropyrimidine-2,4(1H,3H)-dione

Product 1

HCID 226725173-n-Butyl-6-[4-(2-hydroxyethyl)aminophenyl]uracil

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 6-chloro-3-n-butyluracil (10.4 g, 51.3 mmol), 2-(4-aminophenyl)ethanol (10.0 g, 72.9 mmol) and ethyldiisopropylamine (18 ml, 0.1 mol) was heated with stirring under argon on a 150° oil bath for 1 hr 20 min. The mixture was cooled to room temperature, diluted with 50 ml of water, treated with 10 ml of acetic acid and stirred for crystallization overnight. A precipitated solid was filtered, washed with 2% acetic acid, dried on filter and dissolved in 100 ml of hot 96% ethanol. To the solution 100 ml of hot water was added followed by 1.0 g of charcoal. The mixture was filtered hot and crystallized on ice. Yellow solid was collected by filtration and dried in vacuum to yield 10.7 g of 40, mp 207-208 ° C. 1H NMR (DMSO-d6) δ 0.88 (t, 3H, J=7.3 Hz, CH3), 1.25 (m, 2H, CH2), 1.46 (m, 2H, CH2), 2.70 (t, 2H, J=6.8Hz, CH2), 3.60 (dd, 2H, J=11.8, 6.8Hz, CH2), 3.68 (t, 2H, J=7.3Hz, CH2), 4.62 (t, 1H, J=5.3 Hz, OH), 4.73 (d, 1H, J=1.8 Hz, 5-H), 7.10 (d, 2H, J=8.4 Hz, ArH), 7.23 (d, 2H, J=8.4 Hz, ArH), 7.10 (s, 1H, NH), 10.37 (s, 1H, NH).

Workup

  1. temperaturewas heated
  2. stirringstirred for crystallization overnight
  3. filtrationA precipitated solid was filtered
  4. washwashed with 2% acetic acid
  5. customdried
  6. filtrationon filter
  7. dissolutiondissolved in 100 ml of hot 96% ethanol
  8. additionTo the solution 100 ml of hot water was added
  9. filtrationThe mixture was filtered hot
  10. customcrystallized on ice
  11. filtrationYellow solid was collected by filtration
  12. customdried in vacuum

Sources & evidence

ORD record
ord-b3359d0b89da45c7a5553aa78e5169d1
Source dataset
uspto-grants-2004_04
Patent number
US06727356B1

Reaction notes

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