Ethanol → N-(5-Chloro-2-{3-[4-(5-fluoro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)piperidin-1-yl]-2-hydroxy-propoxy}-phenyl)-acetamide

HRID 208725Notes

Reaction equation

HRID 208725 reaction equation
[CH3:38][CH2:39][OH:40].[CH:34]([OH:35])([CH3:36])[CH3:37].[Cl:18][c:19]1[cH:20][cH:21][c:22]([O:29][CH2:30][CH:31]2[O:32][CH2:33]2)[c:23]([NH:25][C:26]([CH3:27])=[O:28])[cH:24]1.[F:1][c:2]1[cH:3][c:4]2[c:5]([n:6]([CH:10]3[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]3)[c:7](=[O:9])[nH:8]2)[cH:16][cH:17]1>>[F:1][c:2]1[cH:3][c:4]2[c:5]([n:6]([CH:10]3[CH2:11][CH2:12][N:13]([CH2:33][CH:31]([CH2:30][O:29][c:22]4[cH:21][cH:20][c:19]([Cl:18])[cH:24][c:23]4[NH:25][C:26]([CH3:27])=[O:28])[OH:32])[CH2:14][CH2:15]3)[c:7](=[O:9])[nH:8]2)[cH:16][cH:17]1

Participants

5

Reactant 4

HCID 702EthanolHCID 3776IsopropanolHCID 137921045-Fluoro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-oneHCID 22313737N-(5-chloro-2-oxiranylmethoxy-phenyl)-acetamide

Product 1

HCID 69198974N-(5-Chloro-2-{3-[4-(5-fluoro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)piperidin-1-yl]-2-hydroxy-propoxy}-phenyl)-acetamide

Sources & evidence

ORD record
ord-a9b74bdb99bc4dcfadb08924925f5606
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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