Methanol → (+/-)-3,4-bis-cyclopropylmethoxy-N-[(1RS,2RS,5RS)-2-(3,4-dimethoxyphenyl)-5-hydroxycyclohexyl]benzamide

HRID 208762Notes

Reaction equation

HRID 208762 reaction equation
[BH4-:37].[CH3:39][OH:40].[CH3:42][C:43]([OH:44])([CH3:45])[CH3:46].[CH3:47][CH2:48][O:49][C:50](=[O:51])[CH3:52].[CH:1]1([CH2:4][O:5][c:6]2[cH:7][c:8]([C:9](=[O:10])[NH:11][CH:12]3[CH2:13][CH:14]4[O:15][CH:16]4[CH2:17][CH:18]3[c:19]3[cH:20][c:21]([O:27][CH3:28])[c:22]([O:25][CH3:26])[cH:23][cH:24]3)[cH:29][cH:30][c:31]2[O:32][CH2:33][CH:34]2[CH2:35][CH2:36]2)[CH2:2][CH2:3]1.[Na+:38].[OH2:41]>>[CH:1]1([CH2:4][O:5][c:6]2[cH:7][c:8]([C:9](=[O:10])[NH:11][CH:12]3[CH2:13][CH:14]([OH:15])[CH2:16][CH2:17][CH:18]3[c:19]3[cH:20][c:21]([O:27][CH3:28])[c:22]([O:25][CH3:26])[cH:23][cH:24]3)[cH:29][cH:30][c:31]2[O:32][CH2:33][CH:34]2[CH2:35][CH2:36]2)[CH2:2][CH2:3]1

Participants

8

Reactant 7

HCID 887MethanolHCID 923Sodium ionHCID 962WaterHCID 6386tert-ButanolHCID 8857Ethyl AcetateHCID 28123BorohydrideHCID 86601279(+/-)-3,4-bis-cyclopropylmethoxy-N-[(3RS,4RS)-4-(3,4-dimethoxyphenyl)-7-oxabicyclo[4.1.0]-hept-3-yl]benzamide

Product 1

HCID 68986614(+/-)-3,4-bis-cyclopropylmethoxy-N-[(1RS,2RS,5RS)-2-(3,4-dimethoxyphenyl)-5-hydroxycyclohexyl]benzamide

Sources & evidence

ORD record
ord-23bf38fb1151471cb8e19cab1a85ad76
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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