2,4-Dichlorophenyl isocyanate → N-{3-[1-(6-{[(2,4-Dichloroanilino)carbonyl]amino}hexyl)-4-piperidinyl]phenyl}-2-methylpropanamide

HRID 2087788Notes

Reaction equation

HRID 2087788 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:25])[CH:22]([CH3:24])[CH3:23])[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1.[Cl:26][C:27]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:28]=1[N:34]=[C:35]=[O:36]>C1COCC1>[Cl:26][C:27]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:28]=1[NH:34][C:35]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:25])[CH:22]([CH3:23])[CH3:24])[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=[O:36]

Participants

4

Reactant 2

HCID 757892,4-Dichlorophenyl isocyanateHCID 16755868N-{3-[1-(6-Aminohexyl)4-piperidinyl]phenyl}-2-methylpropanamide

Product 1

HCID 22725357N-{3-[1-(6-{[(2,4-Dichloroanilino)carbonyl]amino}hexyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(6-aminohexyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 2,4-dichlorophenyl isocyanate: ESMS m/e: 533.2 (M+H)+.

Sources & evidence

ORD record
ord-c6a34a7772784f109fd3d2b5db073d32
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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