2,2-Diphenylacetyl chloride → N-[3-(1-{5-[(Diphenylacetyl)amino]pentyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 2087810Notes

Reaction equation

HRID 2087810 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:14]=[C:15]([NH:19][C:20](=[O:24])[CH:21]([CH3:23])[CH3:22])[CH:16]=[CH:17][CH:18]=2)[CH2:9][CH2:8]1.[C:25]1([CH:31]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:32](Cl)=[O:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>C1COCC1.C(Cl)Cl>[C:35]1([CH:31]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:32]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]2[CH2:8][CH2:9][CH:10]([C:13]3[CH:14]=[C:15]([NH:19][C:20](=[O:24])[CH:21]([CH3:22])[CH3:23])[CH:16]=[CH:17][CH:18]=3)[CH2:11][CH2:12]2)=[O:33])[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

4

Reactant 2

HCID 746372,2-Diphenylacetyl chlorideHCID 16755867N-{3-[1-(5-aminopentyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Product 1

HCID 16755967N-[3-(1-{5-[(Diphenylacetyl)amino]pentyl}-4-piperidinyl)phenyl]-2-methylpropanamide

Reagents, catalysts & solvents 1

HCID 21919333Tetrahydrofurane dichloromethaneSolvent

Procedure

Prepared by Procedure Q2 (THF/DCM, 1:3)) and Scheme AT using N-{3-[1-(5-aminopentyl)-4-piperidinyl]phenyl}-2-methylpropanamide and diphenylacetyl chloride: ESMS m/e: 526.0 (M+H)+.

Sources & evidence

ORD record
ord-78d306d594fb4db9a0232c6f3a79a68c
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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