5-(3,5-dichlorophenoxy)furan-2-carbonyl chloride → 5-(3,5-Dichlorophenoxy)-N-(4-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}butyl)-2-furamide

HRID 2087812Notes

Reaction equation

HRID 2087812 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:13]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[CH:15]=[CH:16][CH:17]=2)[CH2:8][CH2:7]1.[Cl:24][C:25]1[CH:26]=[C:27]([CH:37]=[C:38]([Cl:40])[CH:39]=1)[O:28][C:29]1[O:33][C:32]([C:34](Cl)=[O:35])=[CH:31][CH:30]=1>C1COCC1.C(Cl)Cl>[Cl:24][C:25]1[CH:26]=[C:27]([CH:37]=[C:38]([Cl:40])[CH:39]=1)[O:28][C:29]1[O:33][C:32]([C:34]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[CH2:7][CH2:8][CH:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:21])[CH3:22])[CH:13]=3)[CH2:10][CH2:11]2)=[O:35])=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 27360285-(3,5-dichlorophenoxy)furan-2-carbonyl chlorideHCID 16757471N-{3-[1-(4-Aminobutyl)4-piperidinyl]phenyl}-2-methylpropanamide

Product 1

HCID 220495305-(3,5-Dichlorophenoxy)-N-(4-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}butyl)-2-furamide

Reagents, catalysts & solvents 1

HCID 21919333Tetrahydrofurane dichloromethaneSolvent

Procedure

Prepared by Procedure Q2 (THF/DCM, 1:3) and Scheme AT using N-{3-[1-(4-aminobutyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 5-(3,5-dichlorophenoxy)-2-furoyl chloride: ESMS m/e: 572.0 (M+H)+.

Sources & evidence

ORD record
ord-d0feceae64b44a0e89a4b4dff275733e
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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