Potassium Carbonate → N-(3-{1-[4-(4-Tert-butylphenyl)-4-oxobutyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 2088085Notes

Reaction equation

C([O-])([O-])=O.[K+].[K+].[CH3:7][CH:8]([CH3:24])[C:9]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH:13]=1)=[O:10].[C:25]([C:29]1[CH:34]=[CH:33][C:32]([C:35](=[O:40])[CH2:36][CH2:37][CH2:38]Cl)=[CH:31][CH:30]=1)([CH3:28])([CH3:27])[CH3:26]>>[C:25]([C:29]1[CH:30]=[CH:31][C:32]([C:35](=[O:40])[CH2:36][CH2:37][CH2:38][N:21]2[CH2:22][CH2:23][CH:18]([C:14]3[CH:13]=[C:12]([NH:11][C:9](=[O:10])[CH:8]([CH3:24])[CH3:7])[CH:17]=[CH:16][CH:15]=3)[CH2:19][CH2:20]2)=[CH:33][CH:34]=1)([CH3:28])([CH3:27])[CH3:26]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 27236944'-tert-Butyl-4-chlorobutyrophenone

HCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22049598N-(3-{1-[4-(4-Tert-butylphenyl)-4-oxobutyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure K (KI) and Scheme E (K2CO3) using 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide and 1-(4-tert-butylphenyl)-4-chloro-1-butanone: ESMS m/e: 449.2 (M+H)+.

Sources & evidence

ORD record: ord-0ef457ff98e1442181d9a64bb31909af
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06727264B1

Reaction notes

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