反应详情

温度

0 °C

(1R*,2R*,5R*)-2-{[3,5-Bis(trifluoromethyl)phenyl]methoxy}-8-(2-hydroxyethyl)-1-phenyl-8-azabicyclo[3.2.1]octane (Example 67; 173 mg, 0.37 mmol) was dissolved in dichloromethane (2 ml) and cooled to 0° C. Triethylamine (0.062 ml, 0.44 mmol) was added followed by methanesulphonyl chloride (0.029 ml, 0.37 mmol). The mixture was extracted between water and dichloromethane (×3) and the organics dried (MgSO4) and concentrated in vacuo to give the title compound as a clear oil (201 mg, 100%).

1. extractionThe mixture was extracted between water and dichloromethane (×3)
2. dry with materialthe organics dried (MgSO4)
3. concentrationconcentrated in vacuo