5-(trifluoromethyl)pyridine-2-carboxylic Acid → HCID 59331162, compound

HRID 2088317Notes

Reaction equation

HRID 2088317 reaction equation
COC1C=CC=CC=1C([NH:7][C@H:8]1[CH:13]2[CH2:14][CH2:15][N:10]([CH2:11][CH2:12]2)[CH2:9]1)=O.[F:20][C:21]([F:32])([F:31])[C:22]1[CH:23]=[CH:24][C:25]([C:28]([OH:30])=O)=[N:26][CH:27]=1>>[N:10]12[CH2:15][CH2:14][CH:13]([CH2:12][CH2:11]1)[C@@H:8]([NH:7][C:28]([C:25]1[CH:24]=[CH:23][C:22]([C:21]([F:20])([F:32])[F:31])=[CH:27][N:26]=1)=[O:30])[CH2:9]2

Participants

3

Reactant 2

HCID 109103495-(trifluoromethyl)pyridine-2-carboxylic AcidHCID 44286533HCID 44286533, compound

Product 1

HCID 59331162HCID 59331162, compound

Procedure

Title compound was synthesized according to the procedure used in the synthesis of Compound 19S, using 5-(trifluoromethyl)picolinic acid in place of o-methoxybenzoic acid. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.98 (s, 1H), 8.22 (dd, J=8 Hz, 1H), 7.71 (d, J=8 Hz, 1H), 6.36 (s, 1H), 4.11 (m, 1H), 3.39 (dd, J=16 Hz, 1H), 2.83-2.77 (m, 4H), 2.56 (ddd, J=16 Hz, 1H), 2.00 (m, 1H), 1.66 (m, 3H), 1.50 (m, 1H). C14H16F3N3O=299.12 LCMS (M+H): m/z 300

Sources & evidence

ORD record
ord-2125a0946204422fb05df74e00bee6c7
Source dataset
uspto-grants-2013_05
Patent number
US08435762B2

Reaction notes

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