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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 208832Generated: October 31, 2026

Toluene → 4-Chloromethyl-5-(4-trifluoromethylphenyl)isoxazole

https://huagongshe.com/reaction/208832

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
ReactantTetrahydrofuranHCID 8028—
ReactantThionyl ChlorideHCID 24386—
Reactant5-(4-Trifluoromethylphenyl)-4-isoxazolylmethanolHCID 22221425—
Product4-Chloromethyl-5-(4-trifluoromethylphenyl)isoxazoleHCID 22221193—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
ORD IDord-a11c2deed740431cbcf7121d490ec970
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (6/10)