2,5-Dimethoxybenzoic acid → HCID 45381614, compound

HRID 2088320Notes

Reaction equation

HRID 2088320 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[C:18](OC)[CH:17]=[CH:16][C:4]=1[C:5]([NH:7][C@H:8]1[CH:13]2[CH2:14][CH2:15][N:10]([CH2:11][CH2:12]2)[CH2:9]1)=[O:6].[CH3:22][O:23]C1C=CC(OC)=CC=1C(O)=O>>[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:17]([O:23][CH3:22])=[CH:16][C:4]=1[C:5]([NH:7][C@H:8]1[CH:13]2[CH2:12][CH2:11][N:10]([CH2:15][CH2:14]2)[CH2:9]1)=[O:6]

Participants

3

Reactant 2

HCID 760272,5-Dimethoxybenzoic acidHCID 45381408HCID 45381408, compound

Product 1

HCID 45381614HCID 45381614, compound

Procedure

Title compound was synthesized according to the procedure used in the synthesis of Compound 88S using 2,5-dimethoxybenzoic acid in place of 2,4-dimethoxybenzoic acid. 1H NMR (400 MHz, Acetone-D4) δ (ppm): 7.61 (m, J=4 Hz, 1H), 7.11 (s, 1H), 7.07 (m, J=4 Hz, 1H), 4.07 (m, 1H), 4.00 (s, 3H), 3.80 (s, 3H), 3.34 (s, 3H), 2.89-2.82 (m, 4H), 2.62 (m, 1H), 1.98 (m, 1H), 1.84 (m, 1H), 1.84 (m, 2H), 1.52 (m, 1H). C16H22N2O3=290.16 LCMS (M+H): m/z 291

Sources & evidence

ORD record
ord-c163a065aa9f44c9b5d9ab4a1a4a842d
Source dataset
uspto-grants-2013_05
Patent number
US08435762B2

Reaction notes

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