2-Methoxynicotinic acid → HCID 59331197, compound

HRID 2088321Notes

Reaction equation

HRID 2088321 reaction equation
[CH3:1][O:2][C:3]1C=[CH:18][CH:17]=[CH:16][C:4]=1[C:5]([NH:7][C@H:8]1[CH:13]2[CH2:14][CH2:15][N:10]([CH2:11][CH2:12]2)[CH2:9]1)=[O:6].COC1[N:30]=CC=CC=1C(O)=O>>[CH3:1][O:2][C:3]1[C:4]([C:5]([NH:7][C@H:8]2[CH:13]3[CH2:12][CH2:11][N:10]([CH2:15][CH2:14]3)[CH2:9]2)=[O:6])=[CH:16][CH:17]=[CH:18][N:30]=1

Participants

3

Reactant 2

HCID 7080932-Methoxynicotinic acidHCID 44286533HCID 44286533, compound

Product 1

HCID 59331197HCID 59331197, compound

Procedure

Title compound was synthesized according to the procedure used in the synthesis of Compound 19S, using 2-methoxynicotinic acid in place of o-methoxybenzoic acid. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.51 (dd, J=8 Hz 1H), 8.28 (dd, J=6 Hz 1H), 7.07 (dd, J=8 Hz 1H), 4.16 (s, 3H, m, 1H), 3.44 (dd, J=12 Hz, 1H), 2.92 (t, J=8 Hz 2H), 2.85 (m, 2H), 2.61 (ddd, J=16, 12 Hz, 1H), 2.03 (m, 1H), 1.75 (m, 3H), 1.59 (m, 1H). C14H19N3O2=261.15 LCMS (M+H): m/z 262

Sources & evidence

ORD record
ord-28b7f54d81024b58b58af68fea6145ef
Source dataset
uspto-grants-2013_05
Patent number
US08435762B2

Reaction notes

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