Trifluoroacetic acid → HCID 59578334, compound

HRID 2088402Notes

Reaction equation

HRID 2088402 reaction equation
[CH:1]1([NH:4][C:5](=[O:30])[CH:6]([OH:29])[CH:7]([NH:11][C:12]([C@@H:14]2[C@H:18]3[CH2:19][CH2:20][CH2:21][C@H:17]3[CH2:16][N:15]2C(OC(C)(C)C)=O)=[O:13])[CH2:8][CH2:9][CH3:10])[CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:1]1([NH:4][C:5](=[O:30])[CH:6]([OH:29])[CH:7]([NH:11][C:12]([C@@H:14]2[C@H:18]3[CH2:19][CH2:20][CH2:21][C@H:17]3[CH2:16][NH:15]2)=[O:13])[CH2:8][CH2:9][CH3:10])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68767097HCID 68767097, compound

Product 1

HCID 59578334HCID 59578334, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Compound 12 (0.845 g, 2 mmol) is treated with TFA (5 ml) in DCM (10 ml) at 0° C. for 2 hr. The mixture is evaporated to dryness. The yellow syrup so obtained is dissolved in DCM (20 ml) to make a stock solution of 13 (0.1 M) for the next step.

Workup

  1. customThe mixture is evaporated to dryness
  2. customThe yellow syrup so obtained

Sources & evidence

ORD record
ord-a53946da24884ebba7454fdffe633795
Source dataset
uspto-grants-2013_05
Patent number
US08435984B2

Reaction notes

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