反应详情

温度

90 °C

49 mg (0.41 mmol) of 1H-benzotriazole, 150 mg (0.41 mmol) of 4-{2-[2-(3-chloromethylphenyl)pyrimidin-5-yloxy]ethyl}morpholine hydrochloride and 136 mg (1.62 mmol) of sodium hydrogencarbonate are suspended in 4 ml of acetonitrile and stirred at 90° C. for 18. Water is added to the reaction mixture, which is then extracted with ethyl acetate. The organic phase is dried over sodium sulfate, evaporated and purified by means of column chromatography on silica gel.

1. extractionis then extracted with ethyl acetate
2. dry with materialThe organic phase is dried over sodium sulfate
3. customevaporated
4. custompurified by means of column chromatography on silica gel