反应详情

In a microwave safe sealed tube was charged a mixture of ((S)-tert-butyl 1-(3-(2-bromothiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate (96.5 mg, 0.2 mmol), 2-Fluorophenylboronic acid (33.6 mg, 0.24 mmol), 1,1′-Bis(diphenylphosphino)ferrocene palladium (II) chloride (81.7 mg, 0.1 mmol), 1.00 M of Potassium acetate in Water (0.3 mL, 0.3 mmol), 1.00 M of Sodium carbonate in Water (0.3 mL, 0.3 mmol) in acetonitrile (5 mL). The mixture was irradiated at 300 W 110° C. for 15 minutes. The reaction mixture was then concentrated and the residue was purified on silica eluting with 0 to 5% MeOH in DCM with 1% NH4OH (90.0 mg, 90.4%). ESIMS m/z=498.2 (M+1).

1. additionIn a microwave safe sealed tube was charged
2. customThe mixture was irradiated at 300 W 110° C. for 15 minutes
3. concentrationThe reaction mixture was then concentrated
4. customthe residue was purified on silica eluting with 0 to 5% MeOH in DCM with 1% NH4OH (90.0 mg, 90.4%)