Hydrochloric Acid → HCID 57755826, compound

Participants

Reaction Steps

4-(4-Fluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (3.6 g) was suspended in 67 mL MeOH and 2.5 M NaOH (23 mL) was added. The mixture was heated at 65° for 6 hours, then cooled, diluted with water and acidified with conc. HCl. The resulting precipitate was recovered by filtration and air dried to yield 4-(4-fluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid(2.3 g).

Provenance & Evidence