Hydrochloric Acid → HCID 57755826, compound

HRID 2088444Notes

Reaction equation

HRID 2088444 reaction equation
C([O:3][C:4]([C:6]1[CH:7]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[NH:8][C:9](=[O:12])[NH:10][CH:11]=1)=[O:5])C.[OH-].[Na+].Cl>CO.O>[F:19][C:16]1[CH:17]=[CH:18][C:13]([CH:7]2[C:6]([C:4]([OH:5])=[O:3])=[CH:11][NH:10][C:9](=[O:12])[NH:8]2)=[CH:14][CH:15]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66955131HCID 66955131, compound

Product 1

HCID 57755826HCID 57755826, compoundYield 71.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

4-(4-Fluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (3.6 g) was suspended in 67 mL MeOH and 2.5 M NaOH (23 mL) was added. The mixture was heated at 65° for 6 hours, then cooled, diluted with water and acidified with conc. HCl. The resulting precipitate was recovered by filtration and air dried to yield 4-(4-fluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid(2.3 g).

Workup

  1. temperatureThe mixture was heated at 65° for 6 hours
  2. temperaturecooled
  3. filtrationThe resulting precipitate was recovered by filtration and air
  4. customdried

Sources & evidence

ORD record
ord-cc50e35c42f94b26bba9d9408dec9f29
Source dataset
uspto-grants-2013_05
Patent number
US08435990B2

Reaction notes

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