Hydrochloric Acid → HCID 66955021, compound

HRID 2088447Notes

Reaction equation

HRID 2088447 reaction equation
C([O:3][C:4]([C:6]1[CH:7]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[N:8](C)[C:9](=[O:13])[N:10]([CH3:12])[CH:11]=1)=[O:5])C.Cl>CO.[OH-].[Na+]>[F:21][C:18]1[CH:19]=[CH:20][C:15]([CH:7]2[C:6]([C:4]([OH:5])=[O:3])=[CH:11][N:10]([CH3:12])[C:9](=[O:13])[NH:8]2)=[CH:16][CH:17]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58128708HCID 58128708, compound

Product 1

HCID 66955021HCID 66955021, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

4-(4-Fluoro-phenyl)-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (700 mg) was dissolved in a mixture of 20 mL methanol and 6 mL 10% aqueous NaOH and heated at 45° for 3 hours. The reaction mixture was cooled to room temperature and acidified with conc. HCl. The resulting precipitate and collected by filtration and air-dried to give 4-(4-Fluoro-phenyl)-1-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid.

Workup

  1. temperatureheated at 45° for 3 hours
  2. filtrationThe resulting precipitate and collected by filtration
  3. customair-dried

Sources & evidence

ORD record
ord-6a13169b83b441eab1c959f8eb597987
Source dataset
uspto-grants-2013_05
Patent number
US08435990B2

Reaction notes

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