HCID 66955114, compound → HCID 66954979, compound

HRID 2088457Notes

Reaction equation

HRID 2088457 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[C:15]([CH3:16])=[CH:14][CH:13]([C:17]2[CH:22]=[C:21]([NH:23]C(OC(C)(C)C)=O)[C:20]([CH3:31])=[CH:19][C:18]=2[F:32])[NH:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([O:8][C:9]([N:11]1[C:15]([CH3:16])=[CH:14][C:13]([C:17]2[CH:22]=[C:21]([NH2:23])[C:20]([CH3:31])=[CH:19][C:18]=2[F:32])=[N:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 66955114HCID 66955114, compound

Product 1

HCID 66954979HCID 66954979, compoundYield 83.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

3-(5-tert-Butoxycarbonylamino-2-fluoro-4-methyl-phenyl)-5-methyl-2H-pyrazole-1-carboxylic acid benzyl ester (320 mg) was hydrogenated using 10% Pd/C (40 mg) following the procedure of step 2 to give 3-(5-amino-2-fluoro-4-methyl-phenyl)-5-methyl-pyrazole-1-carboxylic acid benzyl ester (205 mg) as a white solid.

Sources & evidence

ORD record
ord-d514f954469e4879be74ce39000be3eb
Source dataset
uspto-grants-2013_05
Patent number
US08435990B2

Reaction notes

Loading…