Hydrochloric Acid → HCID 67228737, compound

HRID 2088662Notes

Reaction equation

HRID 2088662 reaction equation
C(OC(=O)[NH:7][C:8]1[C:13]([C:14](=[O:17])[CH2:15][CH3:16])=[CH:12][CH:11]=[C:10]([NH:18][CH2:19][CH2:20][NH:21]C(OC(C)(C)C)=O)[N:9]=1)(C)(C)C.[ClH:30]>O1CCOCC1.C(OCC)C>[ClH:30].[NH2:7][C:8]1[C:13]([C:14](=[O:17])[CH2:15][CH3:16])=[CH:12][CH:11]=[C:10]([NH:18][CH2:19][CH2:20][NH2:21])[N:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57911744tert-Butyl[6-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-propanoylpyridin-2-yl]carbamate

Product 1

HCID 67228737HCID 67228737, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

530 mg (1.30 mmol) of tert-butyl[6-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-propanoylpyridin-2-yl]carbamate (Example 24A) were dissolved in 15 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 20 h. After the reaction had gone to completion, the reaction mixture was diluted with diethyl ether (100 ml), and the precipitate was filtered off, washed with diethyl ether (100 ml) and dried. This gave 290 mg (91% of theory) of the product as a solid.

Workup

  1. filtrationthe precipitate was filtered off
  2. washwashed with diethyl ether (100 ml)
  3. customdried

Sources & evidence

ORD record
ord-d6a3e4019908441b8c8ff6319398847d
Source dataset
uspto-grants-2013_05
Patent number
US08436003B2

Reaction notes

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