Water → tert-Butyl 4-[7-(2,4-dichlorophenyl)-5-oxo-5,6-dihydro [1,2,4]triazolo[1,5-c]pyrimidin-2-yl]-piperidine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

In a round-bottom flask fitted with reflux condenser and a drying tube filled with calcium chloride, 5.86 g (20.6 mmol) of ethyl[2-cyano-1-(2,4-dichlorophenyl)ethenyl]carbamate and 5.00 g (20.6 mmol) of tert-butyl 4-(hydrazinylcarbonyl)piperidine-1-carboxylate were dissolved in 11 ml of 1-methyl-2-pyrrolidone, and the reaction mixture was stirred at 150° C. for 3 h. The reaction solution was cooled to RT, water (150 ml) was added and the mixture was stirred in an ultrasonic bath for another 2 min. The solid was filtered off with suction and dried under high vacuum. This gave 7.23 g (76% of theory) of the product.

Provenance & Evidence