反应详情

温度

150 °C

In a round-bottom flask fitted with reflux condenser and a drying tube filled with calcium chloride, 5.86 g (20.6 mmol) of ethyl[2-cyano-1-(2,4-dichlorophenyl)ethenyl]carbamate and 5.00 g (20.6 mmol) of tert-butyl 4-(hydrazinylcarbonyl)piperidine-1-carboxylate were dissolved in 11 ml of 1-methyl-2-pyrrolidone, and the reaction mixture was stirred at 150° C. for 3 h. The reaction solution was cooled to RT, water (150 ml) was added and the mixture was stirred in an ultrasonic bath for another 2 min. The solid was filtered off with suction and dried under high vacuum. This gave 7.23 g (76% of theory) of the product.

1. customIn a round-bottom flask fitted
2. temperaturewith reflux condenser and a drying tube
3. temperatureThe reaction solution was cooled to RT
4. stirringthe mixture was stirred in an ultrasonic bath for another 2 min
5. filtrationThe solid was filtered off with suction
6. customdried under high vacuum