Hydrochloric Acid → 7-(2,4-Dichlorophenyl)-2-(piperidin-4-yl)[1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one hydrochloride

HRID 2088677Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2088677
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:14][C:13](=[O:15])[N:12]2[N:16]=[C:17]([CH:19]3[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)[N:18]=[C:11]2[CH:10]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:14][C:13](=[O:15])[N:12]2[N:16]=[C:17]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:18]=[C:11]2[CH:10]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 136104185tert-Butyl 4-[7-(2,4-dichlorophenyl)-5-oxo-5,6-dihydro [1,2,4]triazolo[1,5-c]pyrimidin-2-yl]-piperidine-1-carboxylate

Produkt 1

HCID 1363378137-(2,4-Dichlorophenyl)-2-(piperidin-4-yl)[1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

8.47 g (18.2 mmol) of tert-butyl 4-[7-(2,4-dichlorophenyl)-5-oxo-5,6-dihydro[1,2,4]triazolo[1,5-c]-pyrimidin-2-yl]piperidine-1-carboxylate (Example 42A) and hydrogen chloride in dioxane (4M, 90 ml) were stirred at RT for 3 h, the solvent was then concentrated to half of its original volume, diethyl ether (50 ml) was added and the reaction mixture was stirred for another 2 min. The solid was filtered off and dried. This gave 7.22 g (99% of theory) of the product.

Aufarbeitung

  1. concentrationthe solvent was then concentrated to half of its original volume, diethyl ether (50 ml)
  2. additionwas added
  3. filtrationThe solid was filtered off
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3b005dccc1c04fa98db5130843813cb5
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436003B2

Notizen zur Reaktion

Wird geladen…