Hydrochloric Acid → 7-(2,4-Dichlorophenyl)-2-(piperidin-4-yl)[1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one hydrochloride

関与物質

反応手順

8.47 g (18.2 mmol) of tert-butyl 4-[7-(2,4-dichlorophenyl)-5-oxo-5,6-dihydro[1,2,4]triazolo[1,5-c]-pyrimidin-2-yl]piperidine-1-carboxylate (Example 42A) and hydrogen chloride in dioxane (4M, 90 ml) were stirred at RT for 3 h, the solvent was then concentrated to half of its original volume, diethyl ether (50 ml) was added and the reaction mixture was stirred for another 2 min. The solid was filtered off and dried. This gave 7.22 g (99% of theory) of the product.

情報源と証拠