反应详情

温度

120 °C

25 mg (0.06 mmol) of 5-chloro-7-(2,4-dichlorophenyl)-2-(1-cyclopropylpiperidin-4-yl)-[1,2,4]-triazolo[1,5-c]pyrimidine hydrochloride, 20 mg (0.07 mmol) of 1-[2-amino-6-(piperidin-3-ylamino)pyridin-3-yl]propan-1-one hydrochloride (Example 27A) and 65 μl (0.4 mmol) of N,N-diisopropylethylamine were initially charged in 1.25 ml of DMSO. The mixture was heated in the microwave at 120° C. for 30 min. This gave, after purification of the crude product by preparative HPLC (Method 11), 21 mg (56% of theory) of the product as a solid.

1. customThis gave, after purification of the crude product by preparative HPLC (Method 11), 21 mg (56% of theory) of the product as a solid