HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → 4-((R)-3-(methylamino)pyrrolidin-1-yl)-8-phenyl-5,6,7,8-tetrahydroquinazolin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514397 | — |
| Reactant | tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate | HCID 7019173 | — |
| Reactant | 2-amino-9,9-dimethyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-4-yl 4-methylbenzenesulfonate | HCID 86634880 | — |
| Product | 4-((R)-3-(methylamino)pyrrolidin-1-yl)-8-phenyl-5,6,7,8-tetrahydroquinazolin-2-amine | HCID 44466871 | — |
Reaction Steps
The title compound was prepared according to the procedures of Examples 1E and 1F, substituting the product from Example 9C for the product from Example 1D and substituting (R)-tert-butylmethyl(pyrrolidin-3-yl)carbamate for (R)-tert-butyl pyrrolidin-3-ylcarbamate. 1H NMR (300 MHz, CDCl3) δ 7.24 (m, 2H), 7.16 (t, J=7.29 Hz, 1H), 7.07 (d, J=7.12 Hz, 2H), 4.53 (s, 2H), 3.96 (t, J=6.27 Hz, 1H), 3.74 (m, 3H), 3.47 (m, 1H), 3.29 (m, 1H), 2.73 (m, 2H), 2.49 (d, J=2.71 Hz, 3H), 2.14 (m, 2H), 1.80 (m, 4H). MS (ESI+) m/z 324 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436005B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-85f223f3252c4322bf9f680e6a13903c |
| Source note | uspto-grants-2013_05 |