HCID 86643533, compound → (3-Aminophenyl)methanesulfonamide

HRID 2088721Notes

Reaction equation

HRID 2088721 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][S:11]([NH-:14])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][S:11]([NH2:14])(=[O:12])=[O:13])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 86643533HCID 86643533, compound

Product 1

HCID 13266255(3-Aminophenyl)methanesulfonamideYield 95%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

(3-Nitrophenyl)methanesulfonyl amide (3.5 g, 16 mM) was hydrogenated over Raney-Ni (0.5 g) in methanol at 50° C. and 70 psi for 4 hours. Then the catalyst was filtered off and washed with warm methanol. The combined filtrates were evaporated to give 2.83 g (95%) of (3-amino-phenyl)-methanesulfonamide.

Workup

  1. filtrationThen the catalyst was filtered off
  2. washwashed with warm methanol
  3. customThe combined filtrates were evaporated

Sources & evidence

ORD record
ord-30eace4a6bf24578a0f9337792d5d3b4
Source dataset
uspto-grants-2013_05
Patent number
US08436007B2

Reaction notes

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