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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2088808Generated: November 2, 2026

HCID 58625122, compound → 3-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamine

https://huagongshe.com/reaction/2088808

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 58625122HCID 58625122—
SolventDichloromethaneHCID 6344—
SolventTrifluoroacetic acidHCID 6422—
Product3-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamineHCID 58625123—

Reaction Steps

A mixture of {3-propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-yl}-carbamic acid tert-butyl ester (0.0001 mol) in 10% TFA in DCM (6 mL) was stirred in a reaction vial for 1 hour at room temperature and then the solvent was evaporated. The obtained residue was crystallized from CH3CN, and then the desired product was filtered off, washed with diisopropyl ether and dried under vaccum to yield the title compound as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08436006B2
Source datasetuspto-grants-2013_05
ORD IDord-97f994174f7e4288875dbf6335b31553
Source noteuspto-grants-2013_05