HCID 58625122, compound → 3-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamine

HRID 2088808Notes

Reaction equation

HRID 2088808 reaction equation
C(OC(=O)[NH:7][C:8]1[N:17]([CH2:18][CH2:19][CH3:20])[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][CH2:29][C:30]4[C:35]([CH3:36])=[CH:34][C:33]([CH3:37])=[CH:32][C:31]=4[CH3:38])[CH:23]=3)[CH:14]=2)[N:9]=1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH2:18]([N:17]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][CH2:29][C:30]4[C:31]([CH3:38])=[CH:32][C:33]([CH3:37])=[CH:34][C:35]=4[CH3:36])[CH:23]=3)[CH:14]=2)[N:9]=[C:8]1[NH2:7])[CH2:19][CH3:20]

Participants

4

Reactant 1

HCID 58625122HCID 58625122, compound

Product 1

HCID 586251233-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamine

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of {3-propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-yl}-carbamic acid tert-butyl ester (0.0001 mol) in 10% TFA in DCM (6 mL) was stirred in a reaction vial for 1 hour at room temperature and then the solvent was evaporated. The obtained residue was crystallized from CH3CN, and then the desired product was filtered off, washed with diisopropyl ether and dried under vaccum to yield the title compound as a solid.

Workup

  1. customthe solvent was evaporated
  2. customThe obtained residue was crystallized from CH3CN
  3. filtrationthe desired product was filtered off
  4. washwashed with diisopropyl ether
  5. customdried under vaccum

Sources & evidence

ORD record
ord-97f994174f7e4288875dbf6335b31553
Source dataset
uspto-grants-2013_05
Patent number
US08436006B2

Reaction notes

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