反应详情

A solution of 18.0 g (84.4 mmol) of 2,6-dichloronicotinic acid in 180 ml (3.45 mol) of a 70% solution of ethylamine in water is heated at 50° C. for ten hours. The excess amine is then evaporated off under reduced pressure, and aqueous 10% acetic acid solution is then added until the product precipitates. The beige-coloured solid is filtered off by suction, rinsed with cold water and oven-dried. 10.5 g of the expected product are obtained. Yield=62%. Melting point: 158-160° C.

1. customThe excess amine is then evaporated off under reduced pressure, and aqueous 10% acetic acid solution
2. additionis then added until the product
3. customprecipitates
4. filtrationThe beige-coloured solid is filtered off by suction
5. washrinsed with cold water
6. customoven-dried