Ethylamine → 6-Chloro-2-(ethylamino)nicotinic acid

Participants

Reaction Steps

A solution of 18.0 g (84.4 mmol) of 2,6-dichloronicotinic acid in 180 ml (3.45 mol) of a 70% solution of ethylamine in water is heated at 50° C. for ten hours. The excess amine is then evaporated off under reduced pressure, and aqueous 10% acetic acid solution is then added until the product precipitates. The beige-coloured solid is filtered off by suction, rinsed with cold water and oven-dried. 10.5 g of the expected product are obtained. Yield=62%. Melting point: 158-160° C.

Provenance & Evidence