Ammonium Hydroxide → HCID 178451805, compound

HRID 2088878Notes

Reaction equation

HRID 2088878 reaction equation
F[C:2](F)(F)[C:3]1[N:4]=[C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[NH:6][CH:7]=1.[OH-].[NH4+:24]>>[C:2]([C:3]1[N:4]=[C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[NH:6][CH:7]=1)#[N:24]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 178451801HCID 178451801, compound

Product 1

HCID 178451805HCID 178451805, compoundYield 83%

Conditions

Temperature
60 °C

Procedure

Combine tert-butyl 4-(4-(trifluoromethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (1.50 g, 4.70 mmol) and ammonium hydroxide (90 mL). Heat the reaction mixture at 60° C. for two days. Let cool to room temperature, then filter via Buchner funnel Wash the solids with water and hexanes to give the title compound as a white solid (1.08 g, 83%). MS (ES) m/z=221 [M]+.

Workup

  1. temperatureLet cool to room temperature
  2. filtrationfilter via Buchner funnel
  3. washWash the solids with water and hexanes

Sources & evidence

ORD record
ord-263c2ef5117d40e995b2323055fc0ffc
Source dataset
uspto-grants-2013_05
Patent number
US08436002B2

Reaction notes

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